Ferment and froth? The bubble problem is not worth mentioning for the special defoamer for pharmaceutical fermentation.      
Foaming process analysis:           
Pharmaceutical fermentation produces froth because: the mixing operation in order to make the agents fully mixed and evenly distributed will lead to foam formation. The temperature and pressure in the fermentor will also be affected; and the vigorous growth of the bacteria will also cause bubbles.           
Problems and effects
1: the effect of foam on pharmaceutical fermentation.There are strict requirements for fermentation technology, especially for pharmaceutical fermentation. Therefore, a large number of foam production will seriously hamper the manufacture of drugs. . Problem and impact
2: drug efficacy reduction  In the pharmaceutical fermentor, the stubborn froth which is not easy to disperse will affect the quality of the produced drugs and lead to the decrease of the efficacy.           
Solve the following problems:   1. the special defoamer used in pharmaceutical fermentation can quickly eliminate the large amount of foam produced in the process of antibiotic fermentation, and its chemical properties are stable, which will not affect the efficacy of antibiotics themselves.  2. The defoamer has small surface tension, good diffusion and permeability, no side effects, and does not affect the growth of drug microorganisms. 3., it has excellent temperature resistance, strong acid and alkali resistance, long foam inhibition time, and can satisfy the requirement of controlling foam in the whole fermentation period. It will not cause bad phenomena such as demulsification and bleaching in fermented liquid.           
usage method:  The defoamer is directly added to the foaming system to ensure its uniform dispersion. If dilution is required, the diluent should not be stored for more than 8 hours. For the system with higher foaming temperature (> 60 ℃), it is suggested to add the system before 60 ℃ and disperse evenly to give full play to its maximum effect. According to the factors of viscosity, temperature and agitation of different foaming systems, the more economical dosage is selected in the unit of 10ppm. Generally speaking, the dosage of 30-200ppm can ensure the ideal defoaming effect.